KIF5A

Across TCGA pan-cancer cohorts, KIF5A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KIF5A data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KIF5A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KIF5A expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where KIF5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.909	0.650	.003	23	view →
LUAD	DFS	Quartile	II,III,IV	0.274	1.000	.027	2	view →
CCRCC	OS	Median	All	0.774	1.000	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KIF5A–LSCC (DFS)

Open the LSCC breakdown →