KIF5A

Across TCGA patient cohorts, KIF5A mutation is significantly associated with the RNA expression of many other genes, with 3,849 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF5A-associated genes across cancer lineages are SEC13, RFWD3, and PPM1D. Each is linked with KIF5A in more than 3 cancer types. Because this analysis shows association rather than direction, both KIF5A-to-partner and partner-to-KIF5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC13 grouped by KIF5A-low versus KIF5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF5A→partner) and Y-score (partner→KIF5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC13 →	+0.306	+1.906	<.001	.001	3	4
UCEC	RFWD3 →	+0.436	+1.736	<.001	<.001	3	4
UCEC	PPM1D →	+0.320	+2.209	.001	<.001	3	4
UCEC	GTSE1 →	+0.594	+1.649	<.001	<.001	3	4
SKCM	GMNN →	+0.495	+2.610	.006	.005	3	4
UCEC	KIF20A →	+0.445	+1.180	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,849 associations by consensus.

SEC13 by KIF5A expression — UCEC

Explore this box plot interactively →