KIF5A

Across TCGA patient cohorts, KIF5A mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF5A-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and Gab2. Each is linked with KIF5A in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF5A-to-partner and partner-to-KIF5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by KIF5A-low versus KIF5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF5A→partner) and Y-score (partner→KIF5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.330	+1.415	.001	.008	3	3
LUSC	Caspase-7-cleavedD198 →	+0.473	+2.825	.044	.033	3	2
LUAD	Gab2 →	+0.547	+3.000	.001	.036	3	2
COAD	EGFR →	+0.207	+2.815	.039	.036	3	2
UCEC	14-3-3_beta →	-0.086	-2.060	.002	.004	3	2
UCEC	eIF4E →	+0.149	+2.820	.013	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ASNS by KIF5A expression — UCEC

Explore this box plot interactively →