KIF5A

Across TCGA cell cohorts, KIF5A mutation is significantly associated with the RNA expression of many other genes, with 348 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF5A-associated genes across cancer lineages are GPR139, XPO7, and DEFB118. Each is linked with KIF5A in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF5A-to-partner and partner-to-KIF5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR139 grouped by KIF5A-low versus KIF5A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF5A→partner) and Y-score (partner→KIF5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GPR139 →	+0.036	+6.357	<.001	<.001	3	2
LARGE_INTESTINE	XPO7 →	+0.705	+3.212	.003	.006	3	2
BREAST	DEFB118 →	+0.032	+4.781	<.001	.003	3	2
BLOOD_Myeloma	RAX →	+0.156	+3.906	.002	.009	3	1
OESOPHAGUS	TRIM64B →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	OR6B1 →	+0.013	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 348 associations by consensus.

GPR139 by KIF5A expression — CNS

Explore this box plot interactively →