Across TCGA patient cohorts, KIF4B mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF4B-associated genes across cancer lineages are Cyclin-E2, Cyclin-B1, and p21. Each is linked with KIF4B in more than 3 cancer types. Because this analysis shows association rather than direction, both KIF4B-to-partner and partner-to-KIF4B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF4B→partner) and Y-score (partner→KIF4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.202	+2.610	.016	.005	3	4
UCEC	Cyclin-B1 →	+0.705	+1.999	<.001	<.001	3	3
COAD	p21 →	+0.172	+1.949	.030	.008	3	3
UCEC	PDCD4 →	-0.574	-2.382	<.001	<.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.378	-1.440	.005	.022	3	3
LUAD	Bim →	+0.239	+3.338	.019	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Exploration

KIF4B survival (RNA) · tumor vs normal (RNA) · all KIF4B data types