KIF3B

Across TCGA patient cohorts, KIF3B mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF3B-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Caspase-8, and eEF2. Each is linked with KIF3B in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF3B-to-partner and partner-to-KIF3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by KIF3B-low versus KIF3B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF3B→partner) and Y-score (partner→KIF3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p38-MAPK_pT180_Y182 →	-0.448	-3.169	.009	.018	3	2
SKCM	Caspase-8 →	-0.145	-2.321	.044	.035	3	2
UCEC	eEF2 →	+0.366	+2.222	.001	.009	3	2
UCEC	GAPDH →	+0.506	+2.321	.003	.005	3	2
UCEC	PEA-15_pS116 →	+0.301	+1.523	.007	.008	3	2
UCEC	ASNS →	+0.406	+1.662	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

p38-MAPK_pT180_Y182 by KIF3B expression — SKCM

Explore this box plot interactively →