KIF3A

Across TCGA pan-cancer cohorts, KIF3A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KIF3A data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KIF3A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KIF3A expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where KIF3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	II,III,IV	0.762	0.267	<.001	36	view →
CCRCC	OS	Quartile	III,IV	0.533	0.875	.008	12	view →
LSCC	OS	Tertile	All	0.737	0.936	.015	10	view →
UCEC	DFS	Tertile	All	1.000	0.871	.013	6	view →
GBM	DFS	Median	All	0.832	0.660	.005	5	view →
HNSC	DFS	Quartile	All	0.912	0.721	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KIF3A–PDAC (OS)

Open the PDAC breakdown →