KIF3A

Across TCGA patient cohorts, KIF3A mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF3A-associated genes across cancer lineages are Notch1, ATM, and PDCD4. Each is linked with KIF3A in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF3A-to-partner and partner-to-KIF3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by KIF3A-low versus KIF3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF3A→partner) and Y-score (partner→KIF3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.135	+1.321	.004	.029	3	3
UCEC	ATM →	-0.454	-1.874	.002	.002	3	3
UCEC	PDCD4 →	-0.368	-1.405	.019	.043	3	2
UCEC	STAT3_pY705 →	-0.380	-1.584	<.001	.015	3	2
UCEC	c-Met_pY1235 →	+0.061	+1.584	.014	.009	3	2
UCEC	4E-BP1 →	+0.274	+1.837	.002	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Notch1 by KIF3A expression — UCEC

Explore this box plot interactively →