KIF2C

Across TCGA pan-cancer cohorts, KIF2C mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KIF2C data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KIF2C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KIF2C expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where KIF2C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.915	0.565	.003	19	view →
HNSC	OS	Median	III,IV	0.484	1.000	.038	9	view →
PDAC	OS	Quartile	II,III,IV	0.325	0.580	.013	8	view →
LUAD	DFS	Quartile	III,IV	0.825	0.203	.016	7	view →
GBM	OS	Tertile	All	0.463	0.629	.045	2	view →
CCRCC	DFS	Median	III,IV	0.369	0.865	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KIF2C–LSCC (DFS)

Open the LSCC breakdown →