KIF2A

Across TCGA pan-cancer cohorts, KIF2A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KIF2A data layer compared with 31 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KIF2A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KIF2A expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, CCRCC, and PDAC are the cancer types where KIF2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.919	0.304	.002	72	view →
CCRCC	DFS	Quartile	All	0.608	0.892	.004	25	view →
PDAC	DFS	Quartile	III,IV	0.429	0.780	.044	6	view →
HNSC	OS	Median	All	1.000	0.959	.023	4	view →
GBM	OS	Median	All	0.227	0.498	.022	4	view →
LSCC	OS	Median	III,IV	0.549	0.873	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KIF2A–UCEC (DFS)

Open the UCEC breakdown →