KIF27

Across TCGA pan-cancer cohorts, KIF27 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated KIF27 data layer compared with 21 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher KIF27 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIF27 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

SCLC, HNSC, and UCEC are the cancer types where KIF27 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.082	0.564	.002	24	view →
HNSC	OS	Median	II,III,IV	0.177	0.601	.010	21	view →
UCEC	DFS	Median	All	0.944	0.613	.004	18	view →
KIRC	OS	Median	All	0.227	0.806	<.001	12	view →
LIHC	DFS	Median	II,III,IV	0.074	0.420	<.001	9	view →
LUSC	DFS	Median	All	0.724	0.377	.018	4	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

KIF27–SCLC (DFS)

Open the SCLC breakdown →