KIF27

Across TCGA cell cohorts, KIF27 mutation is significantly associated with the RNA expression of many other genes, with 288 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF27-associated genes across cancer lineages are TRIM64B, PRAMEF9, and OR2L8. Each is linked with KIF27 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF27-to-partner and partner-to-KIF27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM64B grouped by KIF27-low versus KIF27-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF27→partner) and Y-score (partner→KIF27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TRIM64B →	+0.048	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF9 →	+0.022	+5.029	<.001	.006	3	1
LUNG_SCLC	OR2L8 →	+0.155	+5.029	<.001	.006	3	1
BLOOD_Leukemia	LGI1 →	+0.044	+3.316	<.001	.003	3	1
BLOOD_Leukemia	SYCN →	+0.021	+3.316	<.001	.003	3	1
BLOOD_Leukemia	NUTM1 →	+0.054	+3.643	.003	.005	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 288 associations by consensus.

TRIM64B by KIF27 expression — LUNG_SCLC

Explore this box plot interactively →