KIF25

Across TCGA patient cohorts, KIF25 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF25-associated genes across cancer lineages are Caspase-8, EGFR_pY1068, and A-Raf_pS299. Each is linked with KIF25 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF25-to-partner and partner-to-KIF25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by KIF25-low versus KIF25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF25→partner) and Y-score (partner→KIF25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.286	-2.807	.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.232	-1.584	.010	.019	3	1
UCEC	A-Raf_pS299 →	-0.122	-2.000	.004	.030	3	1
UCEC	FASN →	+0.363	+2.222	.010	.010	3	1
UCEC	FoxM1 →	+0.194	+1.584	.037	.019	3	1
UCEC	GATA6 →	-0.137	-1.840	.016	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Caspase-8 by KIF25 expression — UCEC

Explore this box plot interactively →