KIF25

Across TCGA cell cohorts, KIF25 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible KIF25-associated genes across cancer lineages are BMP10, CD300H, and CST9L. Each is linked with KIF25 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF25-to-partner and partner-to-KIF25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP10 grouped by KIF25-low versus KIF25-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF25→partner) and Y-score (partner→KIF25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BMP10 →	+0.036	+4.467	<.001	.004	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1
LUNG_SCLC	CST9L →	+0.060	+5.643	<.001	.002	3	1
LUNG_SCLC	TMIGD1 →	+0.099	+5.029	<.001	.006	3	1
LUNG_SCLC	KRTAP4-3 →	+0.036	+5.643	<.001	.002	3	1
LUNG_SCLC	KRTAP5-11 →	+0.094	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

BMP10 by KIF25 expression — LARGE_INTESTINE

Explore this box plot interactively →