KIF23

Across TCGA cell cohorts, KIF23 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KIF23-associated genes across cancer lineages are OR2L5, GALNTL5, and OR5A2. Each is linked with KIF23 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF23-to-partner and partner-to-KIF23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L5 grouped by KIF23-low versus KIF23-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF23→partner) and Y-score (partner→KIF23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2L5 →	+0.009	+3.472	<.001	.004	3	2
LUNG_NSCLC_LUAD	GALNTL5 →	+0.043	+3.374	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR5A2 →	+0.002	+3.944	<.001	.006	3	1
LARGE_INTESTINE	MMP26 →	+0.039	+3.632	<.001	.003	3	1
BLOOD_Leukemia	PPP1R2C →	+0.240	+4.539	<.001	.007	3	1
BLOOD_Leukemia	SSX3 →	+1.595	+4.409	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR2L5 by KIF23 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →