KIF22

Across TCGA pan-cancer cohorts, KIF22 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KIF22 data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher KIF22 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KIF22 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, SKCM, and UCEC are the cancer types where KIF22 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.108	0.703	<.001	36	view →
SKCM	OS	Median	All	0.353	0.784	.011	12	view →
UCEC	DFS	Median	All	0.961	0.621	.019	8	view →
LIHC	OS	Median	II,III,IV	0.164	0.617	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KIF22–ESCA (OS)

Open the ESCA breakdown →