KIF22

Across TCGA patient cohorts, KIF22 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF22-associated genes across cancer lineages are STAT5a, TSC1, and EGFR. Each is linked with KIF22 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF22-to-partner and partner-to-KIF22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT5a grouped by KIF22-low versus KIF22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF22→partner) and Y-score (partner→KIF22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT5a →	+0.461	+2.700	.003	.006	3	2
SKCM	TSC1 →	-0.255	-3.000	.031	.036	3	1
UCEC	EGFR →	-0.182	-2.000	.003	.010	3	1
UCEC	ERK2 →	+0.196	+1.874	.009	.049	3	1
UCEC	FoxM1 →	+0.230	+2.502	.023	.002	3	1
UCEC	Gab2 →	+0.299	+2.000	.032	.010	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

STAT5a by KIF22 expression — UCEC

Explore this box plot interactively →