KIF22

Across TCGA cell cohorts, KIF22 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,261 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KIF22-associated GO terms across cancer lineages are DNA recombination, Recombinational repair, and Regulation of cell cycle G2/M phase transition. Each is linked with KIF22 in more than 18 cancer types. Because this analysis shows association rather than direction, both KIF22-to-partner and partner-to-KIF22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA recombination grouped by KIF22-low versus KIF22-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF22→partner) and Y-score (partner→KIF22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNA recombination →	+0.077	+0.882	<.001	<.001	3	19
BONE	Recombinational repair →	+0.103	+0.960	<.001	.004	3	19
UPPER_AERODIGESTIVE_TRACT	Regulation of cell cycle G2/M phase transition →	+0.080	+0.972	<.001	<.001	3	19
BLOOD_Lymphoma	Regulation of chromosome organization →	+0.081	+1.095	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Regulation of sister chromatid segregation →	+0.110	+0.847	<.001	.004	3	19
BONE	Nuclear DNA replication →	+0.187	+1.046	<.001	.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,261 associations by consensus.

DNA recombination by KIF22 expression — SOFT_TISSUE

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