KIF22

Across TCGA cell cohorts, KIF22 mutation is significantly associated with the RNA expression of many other genes, with 299 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF22-associated genes across cancer lineages are C5orf46, OR1G1, and CGB8. Each is linked with KIF22 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF22-to-partner and partner-to-KIF22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf46 grouped by KIF22-low versus KIF22-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF22→partner) and Y-score (partner→KIF22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C5orf46 →	+0.099	+3.901	<.001	.006	3	1
BLOOD_Leukemia	OR1G1 →	+0.038	+3.705	.003	.007	3	1
BLOOD_Leukemia	CGB8 →	+0.048	+3.551	.001	.009	3	1
BLOOD_Leukemia	LYZL6 →	+0.023	+4.384	<.001	.006	3	1
LARGE_INTESTINE	TRMU →	+0.784	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ST8SIA5 →	+0.296	+3.184	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 299 associations by consensus.

C5orf46 by KIF22 expression — BLOOD_Leukemia

Explore this box plot interactively →