KIF21A

Across TCGA patient cohorts, KIF21A mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF21A-associated genes across cancer lineages are Cyclin-B1, Fibronectin, and GAPDH. Each is linked with KIF21A in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF21A-to-partner and partner-to-KIF21A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by KIF21A-low versus KIF21A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF21A→partner) and Y-score (partner→KIF21A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Cyclin-B1 →	+0.637	+2.468	.001	.011	3	3
COAD	Fibronectin →	+0.525	+2.178	.030	.035	3	3
COAD	GAPDH →	+0.486	+2.178	.041	.035	3	3
COAD	PCNA →	+0.280	+2.178	.016	.035	3	3
UCEC	ASNS →	+0.443	+1.637	<.001	<.001	3	3
COAD	EGFR_pY1068 →	-0.450	-2.987	.003	.035	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

Cyclin-B1 by KIF21A expression — LUSC

Explore this box plot interactively →