KIF21A

Across TCGA cell cohorts, KIF21A mutation is significantly associated with the RNA expression of many other genes, with 251 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF21A-associated genes across cancer lineages are CCL1, CHRNA2, and DEFB133. Each is linked with KIF21A in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF21A-to-partner and partner-to-KIF21A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL1 grouped by KIF21A-low versus KIF21A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF21A→partner) and Y-score (partner→KIF21A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CCL1 →	+0.234	+3.302	<.001	.003	3	3
LIVER	CHRNA2 →	+0.127	+3.415	<.001	.009	3	2
LIVER	DEFB133 →	+0.044	+3.459	<.001	.004	3	2
LUNG_NSCLC_LUAD	TCTEX1D1 →	+0.530	+2.963	<.001	.004	3	2
BLOOD_Leukemia	PHOX2B →	+0.013	+3.365	.003	.005	3	2
BLOOD_Lymphoma	KRTAP9-2 →	+0.032	+5.247	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 251 associations by consensus.

CCL1 by KIF21A expression — CNS

Explore this box plot interactively →