KIF20A

Across TCGA pan-cancer cohorts, KIF20A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KIF20A data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KIF20A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KIF20A expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where KIF20A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.790	0.940	.019	10	view →
LSCC	DFS	Quartile	All	0.860	0.207	.002	9	view →
LUAD	DFS	Tertile	All	0.481	1.000	.007	8	view →
GBM	DFS	Quartile	All	0.289	0.566	.005	8	view →
PDAC	DFS	Median	III,IV	0.816	0.162	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KIF20A–HNSC (OS)

Open the HNSC breakdown →