KIF1B

Across TCGA pan-cancer cohorts, KIF1B Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated KIF1B data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher KIF1B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KIF1B expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUSC show a favorable association.

BRCA, KIRP, and LUAD are the cancer types where KIF1B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.837	0.964	<.001	28	view →
KIRP	OS	Median	III,IV	0.127	0.811	<.001	27	view →
LUAD	DFS	Median	All	0.210	0.684	<.001	22	view →
BLCA	OS	Median	II,III,IV	0.861	0.400	.008	18	view →
ESCA	OS	Median	II,III,IV	0.136	0.702	.001	12	view →
LGG	OS	Median	All	0.208	0.889	<.001	8	view →
COAD	OS	Median	III,IV	0.237	0.798	<.001	7	view →
SCLC	OS	Median	All	0.055	0.653	<.001	6	view →
LUSC	DFS	Median	All	0.885	0.632	.028	4	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
SARC	DFS	Median	All	0.154	0.594	.009	3	view →
UCEC	DFS	Median	All	0.787	0.621	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

KIF1B–BRCA (OS)

Open the BRCA breakdown →