KIF1B

Across TCGA pan-cancer cohorts, KIF1B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KIF1B data layer compared with 27 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KIF1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KIF1B expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, CCRCC, and HNSC are the cancer types where KIF1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	0.889	0.225	.001	50	view →
CCRCC	OS	Median	All	0.612	1.000	.001	41	view →
HNSC	OS	Quartile	All	0.934	0.743	.010	5	view →
PDAC	DFS	Tertile	All	0.238	0.475	.028	4	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.891	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KIF1B–UCEC (DFS)

Open the UCEC breakdown →