KIF1B

Across TCGA patient cohorts, KIF1B mutation is significantly associated with the total protein of many other genes, with 84 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF1B-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and FOXO3a_pS318_S321. Each is linked with KIF1B in more than 3 cancer types. Because this analysis shows association rather than direction, both KIF1B-to-partner and partner-to-KIF1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by KIF1B-low versus KIF1B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF1B→partner) and Y-score (partner→KIF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.202	+3.182	.001	.009	3	4
COAD	Caspase-7-cleavedD198 →	+1.005	+1.891	<.001	.027	3	4
STAD	FOXO3a_pS318_S321 →	-0.247	-2.563	.001	.010	3	3
STAD	c-Kit →	-0.340	-2.321	.010	.030	3	3
STAD	FASN →	+0.473	+3.185	.006	.009	3	3
STAD	Caveolin-1 →	-0.934	-2.584	.003	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

eIF4E by KIF1B expression — COAD

Explore this box plot interactively →