KIF1B

Across TCGA cell cohorts, KIF1B mutation is significantly associated with the RNA expression of many other genes, with 558 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF1B-associated genes across cancer lineages are HSCB, USP14, and TWNK. Each is linked with KIF1B in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF1B-to-partner and partner-to-KIF1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSCB grouped by KIF1B-low versus KIF1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF1B→partner) and Y-score (partner→KIF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSCB →	+0.439	+2.265	.009	.001	3	2
LARGE_INTESTINE	USP14 →	+0.678	+3.546	<.001	<.001	3	2
LARGE_INTESTINE	TWNK →	+0.475	+2.265	<.001	.001	3	2
LARGE_INTESTINE	EPM2A →	+0.444	+2.265	.002	.001	3	2
LARGE_INTESTINE	PDS5A →	+0.672	+2.949	<.001	<.001	3	2
LARGE_INTESTINE	SCO1 →	+0.572	+2.459	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 558 associations by consensus.

HSCB by KIF1B expression — LARGE_INTESTINE

Explore this box plot interactively →