KIF1A

Across TCGA patient cohorts, KIF1A mutation is significantly associated with the total protein of many other genes, with 96 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF1A-associated genes across cancer lineages are MEK1, STAT3_pY705, and Di-Ras3. Each is linked with KIF1A in more than 3 cancer types. Because this analysis shows association rather than direction, both KIF1A-to-partner and partner-to-KIF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by KIF1A-low versus KIF1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF1A→partner) and Y-score (partner→KIF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.329	+2.137	<.001	<.001	3	4
UCEC	STAT3_pY705 →	-0.281	-1.212	<.001	.009	3	4
UCEC	Di-Ras3 →	-0.188	-1.402	<.001	<.001	3	4
CESC	p90 RSK →	-0.241	-3.000	.047	.033	3	3
STAD	Bap1-c-4 →	+0.341	+3.169	.025	.018	3	3
STAD	ER-alpha →	-0.180	-2.563	.012	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

MEK1 by KIF1A expression — UCEC

Explore this box plot interactively →