Across TCGA patient cohorts, KIF18B mutation is significantly associated with the RNA expression of many other genes, with 2,486 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF18B-associated genes across cancer lineages are DHX37, NOCT, and PELO. Each is linked with KIF18B in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF18B-to-partner and partner-to-KIF18B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF18B→partner) and Y-score (partner→KIF18B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DHX37 →	+0.424	+2.145	<.001	<.001	3	2
UCEC	NOCT →	+0.587	+1.541	<.001	.002	3	2
UCEC	PELO →	+0.333	+1.541	.005	.002	3	2
SKCM	CENPH →	+0.703	+2.613	.001	.005	3	2
UCEC	SKA1 →	+0.630	+2.684	<.001	<.001	3	2
UCEC	SEC13 →	+0.279	+2.032	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,486 associations by consensus.

Exploration

KIF18B survival (RNA) · tumor vs normal (RNA) · all KIF18B data types