Across TCGA patient cohorts, KIF18B mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF18B-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and GSK3-a-b. Each is linked with KIF18B in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF18B-to-partner and partner-to-KIF18B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF18B→partner) and Y-score (partner→KIF18B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.594	+1.505	.005	.034	3	3
SKCM	Cyclin-B1 →	+0.692	+3.334	<.001	.005	3	2
SKCM	GSK3-a-b →	+0.187	+2.459	.012	.020	3	2
UCEC	eIF4E →	+0.157	+2.000	.039	.030	3	1
UCEC	ERK2 →	+0.143	+2.000	.040	.029	3	1
UCEC	Heregulin →	-0.112	-2.222	.011	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

KIF18B survival (RNA) · tumor vs normal (RNA) · all KIF18B data types