KIF18A

Across TCGA patient cohorts, KIF18A mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF18A-associated genes across cancer lineages are ASNS, 14-3-3_beta, and eEF2. Each is linked with KIF18A in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF18A-to-partner and partner-to-KIF18A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by KIF18A-low versus KIF18A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF18A→partner) and Y-score (partner→KIF18A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.418	+2.115	.001	.016	3	3
COAD	14-3-3_beta →	-0.225	-3.144	.025	.019	3	2
UCEC	eEF2 →	+0.309	+1.362	.014	.037	3	2
UCEC	MEK1 →	+0.495	+2.392	<.001	<.001	3	2
UCEC	MSH2 →	-0.231	-1.674	.004	.040	3	2
COAD	Notch1 →	+0.209	+3.178	.021	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ASNS by KIF18A expression — UCEC

Explore this box plot interactively →