KIF18A

Across TCGA cell cohorts, KIF18A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,688 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KIF18A-associated GO terms across cancer lineages are Regulation of mitotic sister chromatid separation, Regulation of metaphase/anaphase transition of cell cycle, and Negative regulation of metaphase/anaphase transition of cell cycle. Each is linked with KIF18A in more than 19 cancer types. Because this analysis shows association rather than direction, both KIF18A-to-partner and partner-to-KIF18A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic sister chromatid separation grouped by KIF18A-low versus KIF18A-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF18A→partner) and Y-score (partner→KIF18A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of mitotic sister chromatid separation →	+0.198	+0.902	<.001	.001	3	20
OESOPHAGUS	Regulation of metaphase/anaphase transition of cell cycle →	+0.145	+0.914	<.001	.001	3	20
OESOPHAGUS	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.192	+1.014	<.001	.001	3	20
OESOPHAGUS	Protein localization to condensed chromosome →	+0.192	+0.888	<.001	.001	3	20
OESOPHAGUS	Regulation of chromosome separation →	+0.206	+1.023	<.001	<.001	3	20
OESOPHAGUS	Negative regulation of chromosome separation →	+0.192	+1.014	<.001	.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,688 associations by consensus.

Regulation of mitotic sister chromatid separation by KIF18A expression — OESOPHAGUS

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