KIF18A

Across TCGA cell cohorts, KIF18A mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF18A-associated genes across cancer lineages are OR12D3, GJA8, and SIGLEC7. Each is linked with KIF18A in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF18A-to-partner and partner-to-KIF18A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D3 grouped by KIF18A-low versus KIF18A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF18A→partner) and Y-score (partner→KIF18A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR12D3 →	+0.025	+3.813	<.001	.001	3	1
LUNG_NSCLC_LUAD	GJA8 →	+0.428	+3.564	<.001	.001	3	1
LUNG_NSCLC_LUAD	SIGLEC7 →	+0.057	+3.536	<.001	.001	3	1
LUNG_NSCLC_LUAD	ZNF716 →	+0.348	+2.882	.004	.009	3	1
LUNG_NSCLC_LUAD	MRGPRG →	+0.020	+3.374	<.001	.002	3	1
LUNG_NSCLC_LUAD	ARGFX →	+0.018	+4.247	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

OR12D3 by KIF18A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →