KIF11

Across TCGA pan-cancer cohorts, KIF11 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KIF11 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KIF11 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KIF11 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where KIF11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.579	.001	37	view →
CCRCC	OS	Quartile	All	1.000	0.603	.026	4	view →
PDAC	DFS	Quartile	III,IV	0.291	0.762	.011	3	view →
GBM	OS	Median	All	0.449	0.635	.033	3	view →
HNSC	OS	Median	IV	0.859	0.614	.008	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KIF11–LSCC (OS)

Open the LSCC breakdown →