KIF11

Across TCGA cell cohorts, KIF11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,997 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KIF11-associated GO terms across cancer lineages are Mitotic G2/M transition checkpoint, Meiotic chromosome segregation, and Chromosome localization. Each is linked with KIF11 in more than 19 cancer types. Because this analysis shows association rather than direction, both KIF11-to-partner and partner-to-KIF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic G2/M transition checkpoint grouped by KIF11-low versus KIF11-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF11→partner) and Y-score (partner→KIF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Mitotic G2/M transition checkpoint →	+0.136	+1.521	<.001	<.001	3	20
OESOPHAGUS	Meiotic chromosome segregation →	+0.190	+1.325	<.001	.001	3	20
BREAST	Chromosome localization →	+0.130	+1.098	<.001	<.001	3	20
BONE	Spindle elongation →	+0.318	+1.322	.001	.002	3	20
UPPER_AERODIGESTIVE_TRACT	Centrosome duplication →	+0.130	+1.273	<.001	.001	3	20
BREAST	Metaphase chromosome alignment →	+0.135	+1.135	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,997 associations by consensus.

Mitotic G2/M transition checkpoint by KIF11 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →