KIF11

Across TCGA cell cohorts, KIF11 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KIF11-associated genes across cancer lineages are PRND, PRSS54, and PAX4. Each is linked with KIF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF11-to-partner and partner-to-KIF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRND grouped by KIF11-low versus KIF11-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF11→partner) and Y-score (partner→KIF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRND →	+0.006	+4.874	.001	.002	3	2
BLOOD_Lymphoma	PRSS54 →	+0.043	+4.867	.001	.009	3	1
BLOOD_Leukemia	PAX4 →	+0.017	+4.276	<.001	.007	3	1
BLOOD_Leukemia	ADRA1A →	+0.214	+4.705	<.001	.003	3	1
BLOOD_Leukemia	CFHR5 →	+0.004	+4.969	<.001	.003	3	1
BLOOD_Leukemia	GPR101 →	+0.141	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PRND by KIF11 expression — BLOOD_Leukemia

Explore this box plot interactively →