KIF11

Across TCGA cell cohorts, KIF11 mutation is significantly associated with the mutation status of many other genes, with 4,204 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF11-associated genes across cancer lineages are NFE2L2, TCF20, and NEFM. Each is linked with KIF11 in more than 3 cancer types. Because this analysis shows association rather than direction, both KIF11-to-partner and partner-to-KIF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NFE2L2 grouped by KIF11-low versus KIF11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF11→partner) and Y-score (partner→KIF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NFE2L2 →	+3.129	+3.129	<.001	<.001	1	4
LARGE_INTESTINE	TCF20 →	+1.527	+2.807	.005	.005	1	3
BLOOD_Leukemia	NEFM →	+2.825	+3.847	.001	.001	1	3
BLOOD_Leukemia	CCDC9 →	+3.285	+3.662	.004	.004	1	3
LARGE_INTESTINE	NRXN2 →	+2.070	+2.807	.002	.002	1	3
LARGE_INTESTINE	CAMKK2 →	+3.222	+2.893	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,204 associations by consensus.

NFE2L2 by KIF11 expression — LARGE_INTESTINE

Explore this box plot interactively →