KIAA1614

Across TCGA patient cohorts, KIAA1614 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA1614-associated genes across cancer lineages are Caspase-7-cleavedD198, GAPDH, and PCNA. Each is linked with KIAA1614 in more than 3 cancer types. Because this analysis shows association rather than direction, both KIAA1614-to-partner and partner-to-KIAA1614 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KIAA1614-low versus KIAA1614-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA1614→partner) and Y-score (partner→KIAA1614) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.895	+2.736	<.001	<.001	3	4
COAD	GAPDH →	+0.693	+2.330	.002	.020	2	4
UCEC	PCNA →	+0.173	+1.999	.008	.002	3	3
UCEC	ATM →	-0.497	-4.074	<.001	<.001	3	3
COAD	MIG-6 →	+0.100	+3.182	.024	.009	3	3
UCEC	14-3-3_beta →	-0.111	-2.558	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by KIAA1614 expression — UCEC

Explore this box plot interactively →