KIAA1217

Across TCGA patient cohorts, KIAA1217 mutation is significantly associated with the total protein of many other genes, with 84 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA1217-associated genes across cancer lineages are Chk1, ATM, and Caspase-8. Each is linked with KIAA1217 in more than 3 cancer types. Because this analysis shows association rather than direction, both KIAA1217-to-partner and partner-to-KIAA1217 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by KIAA1217-low versus KIAA1217-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA1217→partner) and Y-score (partner→KIAA1217) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Chk1 →	+0.345	+3.000	.002	.035	3	4
UCEC	ATM →	-0.573	-1.652	<.001	<.001	3	4
UCEC	Caspase-8 →	-0.174	-2.073	.004	<.001	3	4
STAD	GSK-3_pS9 →	-0.389	-3.459	.010	.004	3	3
UCEC	MEK1 →	+0.307	+1.519	<.001	<.001	3	3
STAD	Src_pY527 →	-0.530	-2.321	.008	.032	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

Chk1 by KIAA1217 expression — LUAD

Explore this box plot interactively →