KIAA0586

Across TCGA pan-cancer cohorts, KIAA0586 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated KIAA0586 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KIAA0586 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated KIAA0586 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, SCLC, and CESC are the cancer types where KIAA0586 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.977	0.594	<.001	32	view →
SCLC	OS	Median	All	0.193	0.594	.001	21	view →
CESC	DFS	Median	II,III,IV	0.184	0.705	.036	12	view →
LIHC	DFS	Median	All	0.014	0.527	<.001	9	view →
PAAD	OS	Median	All	0.132	0.590	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
READ	OS	Median	All	0.281	0.830	.006	3	view →
COAD	OS	Median	All	0.708	0.874	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

KIAA0586–UCEC (DFS)

Open the UCEC breakdown →