KIAA0586

Across TCGA pan-cancer cohorts, KIAA0586 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KIAA0586 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KIAA0586 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KIAA0586 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where KIAA0586 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.280	1.000	.020	8	view →
HNSC	DFS	Quartile	All	0.403	1.000	.038	7	view →
LSCC	DFS	Tertile	II,III,IV	0.252	1.000	.024	4	view →
UCEC	DFS	Median	All	0.904	1.000	.021	2	view →
GBM	DFS	Median	All	0.771	0.456	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KIAA0586–LUAD (OS)

Open the LUAD breakdown →