KIAA0586

Across TCGA patient cohorts, KIAA0586 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA0586-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and PKC-delta_pS664. Each is linked with KIAA0586 in more than 3 cancer types. Because this analysis shows association rather than direction, both KIAA0586-to-partner and partner-to-KIAA0586 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by KIAA0586-low versus KIAA0586-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA0586→partner) and Y-score (partner→KIAA0586) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.097	-2.221	<.001	.001	3	3
UCEC	eIF4E →	+0.183	+1.432	.003	.005	3	3
UCEC	PKC-delta_pS664 →	-0.097	-1.925	.005	.004	3	3
UCEC	Rab25 →	-0.241	-1.736	.013	.006	3	3
COAD	ARID1A →	+0.161	+2.183	.028	.033	3	2
UCEC	STAT3_pY705 →	-0.405	-2.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

14-3-3_beta by KIAA0586 expression — UCEC

Explore this box plot interactively →