KIAA0319

Across TCGA pan-cancer cohorts, KIAA0319 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated KIAA0319 data layer compared with 18 for mass-spec protein.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher KIAA0319 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIAA0319 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

PAAD, UCEC, and LUSC are the cancer types where KIAA0319 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	DFS	Median	All	0.116	0.486	.001	24	view →
UCEC	DFS	Median	II,III,IV	0.933	0.302	.008	22	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	6	view →
BLCA	DFS	Median	IV	0.122	0.469	.022	6	view →
LUAD	DFS	Median	IV	0.333	0.671	.048	6	view →
STAD	DFS	Median	All	0.899	0.381	.028	5	view →
LGG	DFS	Median	All	0.480	0.756	.019	3	view →
GBM	OS	Median	All	0.109	0.415	.032	3	view →
ESCA	OS	Median	II,III,IV	0.344	0.713	.013	3	view →
SKCM	OS	Median	II,III,IV	0.933	0.828	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

KIAA0319–PAAD (DFS)

Open the PAAD breakdown →