KIAA0319

Across TCGA patient cohorts, KIAA0319 mutation is significantly associated with the RNA expression of many other genes, with 4,998 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA0319-associated genes across cancer lineages are H2AZ1, MTHFD2, and SPC24. Each is linked with KIAA0319 in more than 4 cancer types. Because this analysis shows association rather than direction, both KIAA0319-to-partner and partner-to-KIAA0319 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AZ1 grouped by KIAA0319-low versus KIAA0319-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA0319→partner) and Y-score (partner→KIAA0319) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H2AZ1 →	+0.467	+1.954	.001	<.001	3	5
COAD	MTHFD2 →	+0.650	+2.834	<.001	.001	3	5
SKCM	SPC24 →	+0.359	+1.954	.002	<.001	3	5
COAD	TXNL1 →	+0.411	+3.335	.002	.005	3	4
STAD	CKS2 →	+1.029	+3.203	<.001	.009	3	4
STAD	NDUFS4 →	+0.529	+3.236	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,998 associations by consensus.

H2AZ1 by KIAA0319 expression — UCEC

Explore this box plot interactively →