KIAA0319

Across TCGA cell cohorts, KIAA0319 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KIAA0319-associated genes across cancer lineages are SCGB2A1, SMIM28, and KRT71. Each is linked with KIAA0319 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIAA0319-to-partner and partner-to-KIAA0319 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB2A1 grouped by KIAA0319-low versus KIAA0319-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA0319→partner) and Y-score (partner→KIAA0319) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SCGB2A1 →	+0.076	+5.169	<.001	.004	3	2
BLOOD_Myeloma	SMIM28 →	+0.023	+4.807	<.001	.006	3	1
BONE	KRT71 →	+0.203	+5.169	<.001	.004	3	1
BONE	DEFA6 →	+0.743	+5.169	<.001	.004	3	1
BONE	OR6C2 →	+0.219	+5.169	<.001	.004	3	1
BONE	GPR139 →	+0.023	+5.169	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

SCGB2A1 by KIAA0319 expression — BONE

Explore this box plot interactively →