KIAA0100

Across TCGA patient cohorts, KIAA0100 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA0100-associated genes across cancer lineages are Rad50, 4E-BP1, and ATM. Each is linked with KIAA0100 in more than 3 cancer types. Because this analysis shows association rather than direction, both KIAA0100-to-partner and partner-to-KIAA0100 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by KIAA0100-low versus KIAA0100-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA0100→partner) and Y-score (partner→KIAA0100) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.171	-1.664	.009	.019	3	4
UCEC	4E-BP1 →	+0.329	+1.584	<.001	<.001	3	3
UCEC	ATM →	-0.600	-1.765	<.001	<.001	3	3
UCEC	eEF2 →	+0.355	+1.584	<.001	<.001	3	3
BLCA	MSH6 →	+0.345	+2.459	.023	.018	3	3
UCEC	Bak →	+0.210	+1.807	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

Rad50 by KIAA0100 expression — UCEC

Explore this box plot interactively →