KHNYN

Across TCGA pan-cancer cohorts, KHNYN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KHNYN data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KHNYN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KHNYN expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, LSCC, and CCRCC are the cancer types where KHNYN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.916	0.532	.015	14	view →
LSCC	OS	Tertile	II,III,IV	0.934	0.684	.016	7	view →
CCRCC	DFS	Median	III,IV	0.818	0.244	.031	6	view →
LUAD	DFS	Quartile	All	0.402	0.785	.012	6	view →
PDAC	DFS	Quartile	All	0.495	0.262	.035	2	view →
HNSC	DFS	Median	II,III,IV	0.967	0.903	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KHNYN–UCEC (DFS)

Open the UCEC breakdown →