KHNYN

Across TCGA patient cohorts, KHNYN mutation is significantly associated with the RNA expression of many other genes, with 4,249 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KHNYN-associated genes across cancer lineages are RNU7-60P, RNA5SP367, and GRAMD4P1. Each is linked with KHNYN in more than 1 cancer types. Because this analysis shows association rather than direction, both KHNYN-to-partner and partner-to-KHNYN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-60P grouped by KHNYN-low versus KHNYN-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHNYN→partner) and Y-score (partner→KHNYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU7-60P →	+0.600	+5.812	<.001	.003	3	2
CESC	RNA5SP367 →	+0.352	+5.010	<.001	.009	3	2
LUSC	GRAMD4P1 →	+0.033	+5.733	<.001	.001	3	2
LUSC	RNU6-1315P →	+0.559	+4.419	<.001	.006	3	2
BLCA	TRAJ55 →	+0.382	+4.562	<.001	.006	3	2
UCEC	PPP1R11P1 →	+0.212	+2.202	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,249 associations by consensus.

RNU7-60P by KHNYN expression — CESC

Explore this box plot interactively →