KHNYN

Across TCGA patient cohorts, KHNYN mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KHNYN-associated genes across cancer lineages are eIF4E, p27_pT198, and p38-MAPK_pT180_Y182. Each is linked with KHNYN in more than 2 cancer types. Because this analysis shows association rather than direction, both KHNYN-to-partner and partner-to-KHNYN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by KHNYN-low versus KHNYN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHNYN→partner) and Y-score (partner→KHNYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.198	+3.335	.017	.005	3	3
UCEC	p27_pT198 →	+0.086	+2.000	.040	.030	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.459	-1.986	.009	.010	3	2
UCEC	eEF2 →	+0.339	+2.999	.015	.035	3	1
UCEC	eIF4G →	+0.336	+3.321	.005	.009	3	1
UCEC	ERK2 →	+0.182	+2.999	.016	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

eIF4E by KHNYN expression — UCEC

Explore this box plot interactively →