KHNYN

Across TCGA cell cohorts, KHNYN mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KHNYN-associated genes across cancer lineages are OR2T1, AADACL2, and IFITM5. Each is linked with KHNYN in more than 1 cancer types. Because this analysis shows association rather than direction, both KHNYN-to-partner and partner-to-KHNYN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T1 grouped by KHNYN-low versus KHNYN-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHNYN→partner) and Y-score (partner→KHNYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR2T1 →	+0.013	+4.906	<.001	.006	3	1
LARGE_INTESTINE	AADACL2 →	+0.031	+4.141	.002	<.001	3	1
LARGE_INTESTINE	IFITM5 →	+0.618	+3.584	<.001	.006	3	1
OVARY	KRTAP4-8 →	+0.315	+4.029	<.001	.009	3	1
OVARY	SUPT20HL1 →	+0.092	+4.807	<.001	.003	3	1
LARGE_INTESTINE	WDR87 →	+0.016	+3.716	.005	.003	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR2T1 by KHNYN expression — OESOPHAGUS

Explore this box plot interactively →