KHDRBS2

Across TCGA patient cohorts, KHDRBS2 mutation is significantly associated with the RNA expression of many other genes, with 3,264 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KHDRBS2-associated genes across cancer lineages are GPER1, DDIT3, and LMNB2. Each is linked with KHDRBS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both KHDRBS2-to-partner and partner-to-KHDRBS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPER1 grouped by KHDRBS2-low versus KHDRBS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHDRBS2→partner) and Y-score (partner→KHDRBS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPER1 →	-0.669	-3.087	<.001	<.001	3	3
UCEC	DDIT3 →	+0.537	+2.606	<.001	<.001	3	3
UCEC	LMNB2 →	+0.592	+4.140	<.001	<.001	3	3
UCEC	NFATC4 →	-0.403	-1.390	.009	.005	3	3
UCEC	PSMC3IP →	+0.580	+2.606	<.001	<.001	3	3
HNSC	SSX2B →	+0.006	+4.178	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,264 associations by consensus.

GPER1 by KHDRBS2 expression — UCEC

Explore this box plot interactively →